CircFOXK2 Promotes Tumor Growth and Metastasis of Pancreatic Ductal Adenocarcinoma via Complexing with RNA Binding Proteins and Sponging MiR-942
نویسندگان
چکیده
منابع مشابه
Long non-coding RNA BANCR promotes pancreatic ductal adenocarcinoma cell growth and metastasis via affecting epithelial-mesenchymal transition
Background: Long non-coding RNAs (lncRNA) have been shown to play critical roles in the development and progression of cancer. Recent studies reported that lncRNA BANCR was associated with proliferation and metastasis for melanoma and lung cancer. However, the role of BANCR in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Methods: Quantitative real-time PCR (qRT-PCR) was used to dete...
متن کاملCircular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b
Circular RNAs (circRNAs) as a novel type of noncoding RNAs (ncRNAs) are widely studied in the development of human various diseases, including cancer. Here, we found circular RNA hsa_circ_000984 encoded by the CDK6 gene was remarkably upregulated in the tissues of colorectal cancer (CRC) patients and in the CRC cell lines. Moreover, high expression level of hsa_circ_000984 was significantly ass...
متن کاملPancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis.
MUC1 is overexpressed and aberrantly glycosylated in more than 60% of pancreatic ductal adenocarcinomas. The functional role of MUC1 in pancreatic cancer has yet to be fully elucidated due to a dearth of appropriate models. In this study, we have generated mouse models that spontaneously develop pancreatic ductal adenocarcinoma (KC), which are either Muc1-null (KCKO) or express human MUC1 (KCM)...
متن کاملSIRT 1 Overexpression is Associated with Metastasis of Pancreatic Ductal Adenocarcinoma (PDAC) and Promotes Migration and Growth of PDAC Cells
BACKGROUND SIRT 1, as a class III histone deacetylase (HDAC), is implicated in the initiation and progression of malignancies. However, the association of SIRT 1 with tumorigenesis or progression of pancreatic ductal adenocarcinoma (PDAC) is not clear. MATERIAL AND METHODS In our study we investigated SIRT 1 expression in PDAC samples and evaluated the association of SIRT 1 level with the clini...
متن کاملBAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages
The incidence and death rate of pancreatic ductal adenocarcinoma (PDAC) have increased in recent years, therefore the identification of novel targets for treatment is extremely important. Interactions between cancer and stromal cells are critically involved in tumour formation and development of metastasis. Here we report that PDAC cells secrete BAG3, which binds and activates macrophages, indu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pancreatology
سال: 2020
ISSN: 1424-3903
DOI: 10.1016/j.pan.2020.07.369